Whitaker Cardiovascular Institute
The Whitaker Cardiovascular Institute of the School of Medicine,
founded in 1974, stimulates, conducts, and coordinates research
and training related to the prevention and treatment of cardiovascular
disease. Under the leadership of Joseph Loscalzo, MD, PhD, the
institute assists in formulating research projects, developing
grant applications, providing information on sources of funding,
and critically reviewing grant and contract proposals in the cardiovascular
area. Over the past two decades, distinguished research advances
in the area of hypertension, lipid physical chemistry, atherogenesis,
endothelial function, thrombosis, nitric oxide and free radical
biology, and gene therapy have been carried out by the institute's
researchers, who have been singled out by the National Institutes
of Health by the award of notable grant programs, including Specialized
Centers of Research in both hypertension and ischemic heart disease.
The breadth and depth of programs is exemplified by a few examples
of current research topics: the effect of hypertension on the
blood vessel wall; molecular markers for cholesterol transport
in the blood; lipoproteins and atherosclerosis; molecular mechanisms
involved in arterial injury, cardiac ischemia, and infarction;
inhibition of experimental atherosclerosis by antihypertensive
drugs; role of thrombotic determinants in atherosclerosis; oxidative
stress in atherosclerosis; gene therapy of vascular diseases;
gene regulation in megakaryocytes; determinants of vascular function;
gene regulation of apoproteins; endothelial function and dysfunction;
studies on arterial elasticity in peripheral vascular disease;
clinical trials of renin inhibitors and of antiarrhythmic drugs;
investigation into the comparative benefits of therapies for coronary
artery disease; the role of nitric oxide in hypertension; and
the benefit of ACE inhibitors and of inotropic agents in congestive
heart failure. Other research areas include the Framingham Heart
Study, the most highly regarded epidemiological study of cardiovascular
disease in the world.
For further information, write to Director, Whitaker Cardiovascular
Institute,Boston University School of Medicine,700 Albany Street,
Boston, MA 02118;617/638-4018.
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Affiliated Institutions
Cooperative Agreements
Students may receive credit for certain courses at Hebrew College
of Brookline, which offers undergraduate and graduate degree programs
in Hebrew and Jewish Studies. Consortium arrangements permit cross-registration
with Boston College, Brandeis University, and Tufts University.
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11 March 1999
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