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John
A. Porco, Jr.
Professor
Director, Boston University Chemical Methodology and Library Development Center (CMLD-BU)
Synthetic Organic
Chemistry
Office:
LSEB 802
Phone: 617-353-2493
Fax: 617-353-6466
E-mail: porco@bu.edu
Office
hours: By
appointment
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| Degrees |
- B.A. in Chemistry (summa cum laude, with Honors), College of the
Holy Cross, 1985.
- M.S. in Organic Chemistry, Yale University, 1988
- Ph.D. in Organic Chemistry, Harvard University, 1992
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| Honors |
- Arthur C. Cope Scholar Award, 2009
- Briston-Myers Squibb Award, 2003-2005
- National Science Foundation Postdoctoral Fellowship, 1992-1994
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| Affiliations |
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| Teaching |
- CH 204 - Organic Chemistry II
- CH 642 - Organic Reaction Mechanisms
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| Research/Activities |
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My research group is involved in the development of new methodologies
for chemical synthesis and their application to synthesis of complex
natural products and natural product-like molecules. In a number
of projects, "Streamlined" synthesis methods will be
emphasized and developed. "Streamlined Organic Synthesis" has
been coined as a descriptor for methodology that lends itself to
efficient application to parallel organic synthesis and may take
advantage of solid-phase organic synthesis, solution-phase synthesis
relying on solid-supported or heterogenized reagents, or hybrid
synthesis sequences. Targets for synthesis will include pharmacologically
active natural and non-natural products where the preparation of
structural variants will allow us to dissect regulatory interactions
with biomolecules. We place a special emphasis on investigations
to define the structure-function relationships of natural or designed
agents in efforts to understand the origin of their biological
properties. In many instances, we will attempt to redesign particular
target molecules and fine-tune their molecular structure through
the use of combinatorial or parallel synthesis approaches.
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